A term for people whose gender identity differs from the sex they were assigned at birth and who often desire or have undergone medical interventions (such as hormone therapy and/or sex reassignment surgery) to align their body with their gender identity. While historically used, the term "transsexual" is considered dated by some, and transgender is now often used as a more inclusive umbrella term. However, some individuals still identify specifically with "transsexual."

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An abbreviation for Male-to-Female. It describes a transgender or transsexual individual who was assigned male at birth but whose gender identity is female. Many MtF individuals undergo social and/or medical transition to align their physical appearance and social role with their female gender identity. The term "trans woman" is often preferred.

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An abbreviation for Female-to-Male. It describes a transgender or transsexual individual who was assigned female at birth but whose gender identity is male. Many FtM individuals undergo social (e.g., changing name and pronouns) and/or medical (e.g., hormone therapy, surgery) transition to align their physical appearance and social role with their male gender identity. The term "trans man" is often preferred.

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